Projekte

Diffusion models for protein design

Generatives Deep Learning hat das Proteindesign verändert und ermöglicht die Entwicklung neuer Proteinstrukturen, Interaktionen und Funktionen mit hoher Prä…

Mechanoradicals and DOPA in Collagen Tissue

– A role for dihydroxyphenylalanine (DOPA) as a marker of mechanical stress and radical scavenger in collagen – Collagen is responsible for the …

Mechanokinases

Kinases are abundantly present in all cells and involved in the regulation of many important processes, such as cell survival, growth, …

Simulations of Collagen Failure and Mechanoradicals

It has been known for many decades that synthetic polymers subjected to mechanical stress generate mechanoradicals by rupture of chemical bonds. …

Intrinsically disordered Proteins

Intrinsically disordered proteins (IDPs) are a new class of proteins that lack secondary and tertiary structures and instead explore a broad …

Force-triggered blood coagulation

Von Willebrand factor (VWF) is a giant multidomain extracellular blood protein in charge of a key adhesive process during hemostasis: the …

Emulation in simulation

„Emulation in Simulation“ verbindet die HITS-Expertise in computergestützter Statistik und numerischer Simulation, um eine neue Generation von Werkzeugen für …

Beeinflusst der Schreibstil die Wirkung wissenschaftlicher Texte?

Die Bedeutung und Qualität neuer Forschungsergebnisse in einem wissenschaftlichen Artikel wird oft dadurch gemessen, wie häufig dieser Artikel zitiert …

Force distribution analysis (FDA)

Force distribution analysis (FDA) is a method to detect and follow force and stress propagation in proteins, reminiscent of Finite Element …

Mechanical properties of silk

Silk is one of the many biomaterials with mechanical properties not yet reached by synthetic counterparts. Silk fibers have an outstanding …

Mechanical properties of Nacre

Nacre, also known as mother-of-pearl, is a biocomposite located at the inner layer of seashells, with exceptional mechanical properties such as …

Structure-based Drug design

Structure-based design methods have proven effective in every aspect of drug design – from lead discovery, development, through guiding clinical trials. …

Force-driven allostery in proteins

Allostery in proteins plays a significant role such as cell signalling or gene and enzyme regulations. Allostery is characterized by a …

Mechano(bio)chemistry

Chemical and enzymatic reactions can be guided by mechanical stress. While single molecule force spectroscopy is an emerging technique to study …